Perturbations in cerebral oxygen radical formation and membrane order following vitamin E deficiency

The efficacy of apolipoprotein E deficiency in cerebral aneurysm formation.

Subarachnoid hemorrhage due to the rupture of a cerebral aneurysm is a life-threatening disease. Despite this, the detailed mechanisms underlying the initiation and progression of cerebral aneurysm are unclear. The relation of hypercholesterolemia and apolipoprotein E (ApoE) to cerebral aneurysm formation, has been unclear until now. We used, in the present study, a previously established cereb...

Study Of Interaction of Glutathione, Vitamin C and Vitamin E Under Hyperbaric Oxygen

In order to study the interaction of glutathione, vitamin C and vitamin E under hyperoxia (95 % oxygen) and hyperbaric oxygen (2.5 atmospheric pressure), 20 days old male Guinea pigs were fed with basal vitamin C free diet, while receiving a vitamin C supplement of either high concentration (50 mg/day) or low concentration (1 mg/day) for two weeks. Animals were than exposed to hyperoxia and hyp...

Development of a Method for measuring Reactive Oxygen Radicals Levels In Vitro and Study the Effects of Vitamin C and E on Radical Production Reaction

Background: Free radicals and reactive oxygen species(ROS) are the most important factors in formation of oxidative stress reaction. Now, radical damage has been suggested to contribute to a wide variety of diseases such as Alzheimer, atherosclerosis and cancer. Transition metal ions in the presence of the various biomolecules produce these active compounds. The aim of this study is introducing...

Degradation of membrane phospholipids and thiols in peroxide hemolysis: studies in vitamin E deficiency.

Vitamin E Deficiency in the Monkey . Iv .

NEMIA regularly develops in the rhesus monkey (Macaca mulatta) when it is deprived of vitamin E.1 The anemia is accompanied by granulocytosis,’ an increased concentration of bone marrow deoxyribonucleic acid,2 a reduction in the maximal Cr5’ survival time of the erythrocytes,3 a slightly elevated reticulocyte count1 and a prompt reticulocytosis following vitamin E administration. This combinati...